- Benjamin Rush Collections
- Edgar Fahs Smith Memorial Collection
- Elzevier Collection
- Environmental Humanities and Sciences Special Collections
- Fairman Rogers Collection
- Freedoms Foundation Political Pamphlet and Periodical Collection
- History of Computing
- Lawrence J. Schoenberg Collection
- Lewis Mumford Collections
- Library at the Katz CAJS Offprints Collection
- Mark B. Adams Science Fiction Collection
- Medieval and Renaissance Manuscripts (Kislak Center)
- Philadelphia Society for Promoting Agriculture (PSPA)
- Rittenhouse Orrery
- Seybert Collections on Modern Spiritualism
- U. S. Health Activism History Collection (Walter J. Lear U.S. Health Activism History Collection)
- World War I Collections
